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Jack is brought to the hospital, where the doctor tells Nick and Sara that he believes Jack has been lobotomized, as lobotomies in the '30s and '40s were done through the eye socket. Jack's parole officer leads Sara and Brass to Jack, who is living on the street believing he's a pirate. The eye's previous owner was a Jack Landers, who is a convicted sex offender. It is found that each of the eyeballs tests for a different drug, and Wendy informs Sara that one of the eyeballs actually belongs to a male.

Because the disease started in the victim's bloodstream, Grissom wonders if the needles were used to inject something into the victim, not take something out. All of the victim's organs are abscessed due to necrotizing facitis, a flesh-eating disease. He also pulled something from between the victim's teeth. Doc Robbins tells Grissom that the victim had puncture wounds around her glandular areas from large-gauge needles. In the autopsy, David Phillips takes vitreous fluid from the victim's eyes and finds that the one of the eyes' optic nerves has been severed. Due to the dust storm, any shoe prints and tire treads have been blown away. The number 19 is branded into the victim's upper arm.

Her right hand has been cut off and her head has been shaved. The body of a half-naked woman has been found sticking out of the sand. Grissom meets up with Nick and Brass in the desert during a dust storm. While Heather pursues an investigation of her own, the crime lab discovers that the victim's killer has more victims in his past. The CSIs uncover the body of a young woman, Lady Heather's daughter, in the Nevada desert.